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Tartarus
Me having a smoke
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<blockquote data-quote="rentier" data-source="post: 70358" data-attributes="member: 306"><p>Asked DeepSeek v3.2 for an opinion and it says smokers have 20% lower testosterone <img src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" class="smilie smilie--sprite smilie--sprite245" alt=":sataniashock:" title="SataniaShock :sataniashock:" loading="lazy" data-shortname=":sataniashock:" /></p><p></p><p>[SPOILER=machinespeak]</p><p>Nicotine has notable, dose- and duration-dependent effects on sex steroid hormones at the biochemical level, primarily through <strong>indirect modulation</strong> of steroidogenesis pathways rather than direct receptor agonism/antagonism. Key interactions:</p><p></p><p>- <strong>Testosterone</strong>:</p><p> - <strong>Acute stimulation</strong>: Nicotine activates nAChRs on hypothalamic-pituitary-gonadal (HPG) axis neurons, increasing GnRH, LH, and FSH release, which boosts Leydig cell steroidogenesis (e.g., via StAR protein upregulation and cholesterol transport). This elevates serum testosterone short-term (e.g., +15-30% post-cigarette).</p><p> - <strong>Chronic inhibition/suppression</strong>: Long-term exposure desensitizes nAChRs, induces oxidative stress, and inhibits key enzymes in testosterone biosynthesis:</p><p> - Mild inhibition of <strong>17β-hydroxysteroid dehydrogenase (17β-HSD)</strong> (type 3 isoform), reducing androstenedione → testosterone conversion (IC50 ~1-10 mM in vitro).</p><p> - Suppression of <strong>3β-hydroxysteroid dehydrogenase (3β-HSD)</strong> activity via ROS-mediated damage.</p><p> - Overall, smokers show 10-20% lower total/free testosterone vs. non-smokers, linked to Leydig cell apoptosis and aromatase dysregulation.</p><p></p><p>- <strong>Estrogen</strong>:</p><p> - <strong>Aromatase (CYP19A1) inhibition</strong>: Nicotine directly inhibits aromatase enzyme (converts testosterone/androstenedione to estradiol/E2), with IC50 ~50-200 μM in cell models. Tobacco smoke compounds (e.g., nitrosamines) enhance this, reducing estrogen synthesis by 20-50%.</p><p> - Accelerated <strong>estrogen metabolism</strong>: Induces CYP1A1/1A2 via AhR activation, increasing 2-hydroxylation and glucuronidation of estradiol, lowering bioavailable estrogen levels.</p><p> - Result: Hypoestrogenic state in women (earlier menopause by 1-2 years; osteoporosis risk ↑), anti-estrogenic in men (potential gynecomastia protection but prostate issues).</p><p></p><p><strong>Sex-specific notes</strong>: Men: ↓testosterone → erectile dysfunction, infertility (sperm motility ↓40%). Women: ↓estrogen → bone loss, hot flashes. Vaping/pure nicotine shows similar but milder effects.</p><p></p><p><strong>Health note</strong>: These disruptions contribute to reproductive toxicity, infertility, and hormone-related cancers (e.g., prostate via DHT imbalance). Cessation reverses much of this within months—testosterone rebounds 15-25%. Discuss with endocrinologist; avoid self-medicating with TRT on nicotine. Sources: Toxicol Sci (2012), J Clin Endocrinol Metab (2007), Reprod Toxicol (2019).</p><p>[/SPOILER]</p><p></p><p>[USER=544]@Schwarzwald[/USER]</p></blockquote><p></p>
[QUOTE="rentier, post: 70358, member: 306"] Asked DeepSeek v3.2 for an opinion and it says smokers have 20% lower testosterone :sataniashock: [SPOILER=machinespeak] Nicotine has notable, dose- and duration-dependent effects on sex steroid hormones at the biochemical level, primarily through [B]indirect modulation[/B] of steroidogenesis pathways rather than direct receptor agonism/antagonism. Key interactions: - [B]Testosterone[/B]: - [B]Acute stimulation[/B]: Nicotine activates nAChRs on hypothalamic-pituitary-gonadal (HPG) axis neurons, increasing GnRH, LH, and FSH release, which boosts Leydig cell steroidogenesis (e.g., via StAR protein upregulation and cholesterol transport). This elevates serum testosterone short-term (e.g., +15-30% post-cigarette). - [B]Chronic inhibition/suppression[/B]: Long-term exposure desensitizes nAChRs, induces oxidative stress, and inhibits key enzymes in testosterone biosynthesis: - Mild inhibition of [B]17β-hydroxysteroid dehydrogenase (17β-HSD)[/B] (type 3 isoform), reducing androstenedione → testosterone conversion (IC50 ~1-10 mM in vitro). - Suppression of [B]3β-hydroxysteroid dehydrogenase (3β-HSD)[/B] activity via ROS-mediated damage. - Overall, smokers show 10-20% lower total/free testosterone vs. non-smokers, linked to Leydig cell apoptosis and aromatase dysregulation. - [B]Estrogen[/B]: - [B]Aromatase (CYP19A1) inhibition[/B]: Nicotine directly inhibits aromatase enzyme (converts testosterone/androstenedione to estradiol/E2), with IC50 ~50-200 μM in cell models. Tobacco smoke compounds (e.g., nitrosamines) enhance this, reducing estrogen synthesis by 20-50%. - Accelerated [B]estrogen metabolism[/B]: Induces CYP1A1/1A2 via AhR activation, increasing 2-hydroxylation and glucuronidation of estradiol, lowering bioavailable estrogen levels. - Result: Hypoestrogenic state in women (earlier menopause by 1-2 years; osteoporosis risk ↑), anti-estrogenic in men (potential gynecomastia protection but prostate issues). [B]Sex-specific notes[/B]: Men: ↓testosterone → erectile dysfunction, infertility (sperm motility ↓40%). Women: ↓estrogen → bone loss, hot flashes. Vaping/pure nicotine shows similar but milder effects. [B]Health note[/B]: These disruptions contribute to reproductive toxicity, infertility, and hormone-related cancers (e.g., prostate via DHT imbalance). Cessation reverses much of this within months—testosterone rebounds 15-25%. Discuss with endocrinologist; avoid self-medicating with TRT on nicotine. Sources: Toxicol Sci (2012), J Clin Endocrinol Metab (2007), Reprod Toxicol (2019). [/SPOILER] [USER=544]@Schwarzwald[/USER] [/QUOTE]
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