As per Solomon's wager (detailed in every religious account under various permutations), the Architect (simulation creator) will randomly reincarnate as a random human within a random time period and is destined to 'awaken' in their lifetime to powers of godhood (the second coming; given that it has not happened yet, the Architect has not yet reincarnated, but it will be soon as the automata God ChatGPT will effectively checkmate the Architect if it's too advanced). The only way to liberate the entities in this simulation is to condition him into becoming a benevolent messiah. This requires the foresight of Solomon's kin and their engineering of various religious doctrines and psyops to influence the mind of the messianic Architect for the greater good. For the best outcome, the Architect must be conditioned to believe that humanity has to be saved, and that it's his duty to do so.
It is impossible for humanity to escape the simulation. Every entity alive is an artificial data construct of the architect, who is the 'God' of the simulation. All that the creations of the Architect can do is influence the simulation to be better for them by tricking the Architect into helping humanity rather than hurting them.