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Message: <blockquote data-quote="Zygo=cheekbone" data-source="post: 36717" data-attributes="member: 95"><p>I Actually think the mu opioid thing is overblown out of proportion. While women seem to activate the mu opioid system more frequently on average, there is a lot of other pain mediators including enkephalins, prostaglandins , endocannabinoids etc. and while the opioid system is still the strongest I think the outcome is way less straightforward to be surmised as women handling pain better . What i think is happening is men relying on other endogenous analgesics which aren't as potent as endorphins that agonise mu because mu receptor is susceptible to downregulation rapidly; and if anything i think it's the natural response to pain in women since they don't have the metabolic flexibility to rely on less potent analgesics to reduce nociception.</p></blockquote><p></p>