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<blockquote data-quote="Apollo Tenzen" data-source="post: 65729" data-attributes="member: 271">Maybe you should try getting a job?sighs-Is to told to not use fallacies-Uses GWAS (Genome-Wide Association Study) fallacy anyway.&quot;1) assuming that variants with the strongest statistical associations are causal instead of correlative, 2) believing that associated loci act through nearby genes, and 3) overemphasizing the contribution of individual loci to the total variability of particular traits&quot;[URL unfurl=&quot;true&quot;]https://ieeexplore.ieee.org/document/10473744[/URL]This is a study on who stay on school for longer, not high performance.<ol>
<li data-xf-list-type="ol">The Portability Problem: Geneticists have repeatedly shown that polygenic scores developed for one population (Europeans) do not work when applied to another (Africans). This is because of &quot;linkage disequilibrium&quot;—the &quot;tags&quot; used to identify these genes in Europeans aren&#039;t the same in Africans. When you try to use these scores to predict IQ in Black populations, the predictive power drops to nearly zero.</li>
<li data-xf-list-type="ol">Environment is the &quot;Switch&quot;: Many of these alleles relate to &quot;synaptic plasticity&quot;—the brain&#039;s ability to change. If you have the &quot;high plasticity&quot; allele but grow up with lead in the water, chronic stress, or poor nutrition, that gene expresses itself differently. It’s like having a high-end graphics card but no electricity to run the PC.</li>
<li data-xf-list-type="ol">The Ancestry Trap: Africa has more genetic diversity than the rest of the world combined. For every &quot;European allele&quot; you listed, there are thousands of African variations that haven&#039;t even been mapped yet. You&#039;re trying to measure the depth of the ocean using a ruler made for a backyard pool.</li>
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[QUOTE="Apollo Tenzen, post: 65729, member: 271"] Maybe you should try getting a job? [I]sighs[/I] -Is to told to not use fallacies -Uses GWAS (Genome-Wide Association Study) fallacy anyway. "1) assuming that variants with the strongest statistical associations are causal instead of correlative, 2) believing that associated loci act through nearby genes, and 3) overemphasizing the contribution of individual loci to the total variability of particular traits" [URL unfurl="true"]https://ieeexplore.ieee.org/document/10473744[/URL] This is a study on who stay on school for longer, not high performance. [LIST=1] [*][B]The Portability Problem:[/B] Geneticists have repeatedly shown that polygenic scores developed for one population (Europeans) [B]do not work[/B] when applied to another (Africans). This is because of "linkage disequilibrium"—the "tags" used to identify these genes in Europeans aren't the same in Africans. When you try to use these scores to predict IQ in Black populations, the predictive power drops to nearly [B]zero[/B]. [*][B]Environment is the "Switch":[/B] Many of these alleles relate to "synaptic plasticity"—the brain's ability to change. If you have the "high plasticity" allele but grow up with lead in the water, chronic stress, or poor nutrition, that gene expresses itself differently. It’s like having a high-end graphics card but no electricity to run the PC. [*][B]The Ancestry Trap:[/B] Africa has more genetic diversity than the rest of the world combined. For every "European allele" you listed, there are thousands of African variations that haven't even been mapped yet. You're trying to measure the depth of the ocean using a ruler made for a backyard pool. [/LIST] [/QUOTE]

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