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Discussion Vorinostat: anxiety and depression nuclear option

Joined
Aug 8, 2025
Messages
4
Vorinostat is a cancer medicine. It is normally used for some lymphomas. It works as an HDAC inhibitor. This means it can turn on some genes that are usually “off” and change how brain cells work PERMANENTLY unlike other depression meds such as lyrica (pregabalin).

Some studies in animals and very small human tests imply Vorinostat helps with severe anxiety and depression. It improves brain plasticity and help the brain “reset” stress responses. This is why some people call it a “nuclear weapon”.

In cancer treatment, the common dose is 400 mg per day (tablet). For anxiety or depression, a 50mg/week sublingual dose is commonly used.

Look up some threads about it on longecity and looksmax.
What do you guys think about this incredibly promising molecule?
 
Forum Regular
Joined
Oct 5, 2024
Messages
495
Social anxiety is clearly one of the worse mental weaknesses for men, hence why such radical solutions.

But an anxious person usually is not a sound logical person, especially under the crushing weight of their mental state. So it follows, its definitely a nuclear potential solution.
 
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